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HSC 70 Polyclonal Antibody

货号：YT2231
应用：WB;ELISA
种属：Human;Mouse;Rat

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靶点：
HSC 70

简介：
>>Spliceosome;>>MAPK signaling pathway;>>Protein processing in endoplasmic reticulum;>>Endocytosis;>>Longevity regulating pathway - multiple species;>>Antigen processing and presentation;>>Estrogen signaling pathway;>>Prion disease;>>Legionellosis;>>Toxoplasmosis;>>Measles;>>Lipid and atherosclerosis

基因名称：
HSPA8

蛋白名称：
Heat shock cognate 71 kDa protein

Human Gene Id：
3312

Human Swiss Prot No：
P11142

Mouse Gene Id：
15481

Mouse Swiss Prot No：
P63017

Rat Gene Id：
24468

Rat Swiss Prot No：
P63018

免疫原：
The antiserum was produced against synthesized peptide derived from human HSC 70. AA range:202-251

特异性：
HSC 70 Polyclonal Antibody detects endogenous levels of HSC 70 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
HSPA8;HSC70;HSP73;HSPA10;Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 8

实测条带：
70kD

背景：
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

功能：
function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,

细胞定位：
Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

组织表达：
Ubiquitous.

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. ONCOGENE 2015 Dec 14 WB Human MCF-7 cell,HEK293T cell
货号：YT2231