HORMAD1 Polyclonal Antibody
- 货号：YT2207
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- HORMA domain-containing protein 1
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human HORMAD1. AA range:321-370
- 特异性：
- HORMAD1 Polyclonal Antibody detects endogenous levels of HORMAD1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- HORMAD1;NOHMA;HORMA domain-containing protein 1;Cancer/testis antigen 46;CT46;Newborn ovary HORMA protein
- 背景：
- This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
- 功能：
- similarity:Contains 1 HORMA domain.,tissue specificity:Testis-specific. Over-expressed in carcinomas.,
- 细胞定位：
- Nucleus . Chromosome . Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). .
- 组织表达：
- Testis-specific. Over-expressed in carcinomas.
- Western Blot analysis of various cells using HORMAD1 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
- Western blot analysis of lysates from HeLa, HUVEC, and COLO cells, using HORMAD1 Antibody. The lane on the right is blocked with the synthesized peptide.
