• 靶点：
• HNF4α

• 简介：
• >>AMPK signaling pathway;>>Maturity onset diabetes of the young

• 基因名称：
• HNF4A

• 蛋白名称：
• Hepatocyte nuclear factor 4-alpha

• Human Gene Id：
• 3172

• Human Swiss Prot No：
• P41235

• Mouse Gene Id：
• 15378

• Mouse Swiss Prot No：
• P49698

• Rat Gene Id：
• 25735

• Rat Swiss Prot No：
• P22449

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human HNF4 alpha. AA range:280-329

• 特异性：
• HNF-4α Polyclonal Antibody detects endogenous levels of HNF-4α protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HNF4A;HNF4;NR2A1;TCF14;Hepatocyte nuclear factor 4-alpha;HNF-4-alpha;Nuclear receptor subfamily 2 group A member 1;Transcription factor 14;TCF-14;Transcription factor HNF-4

• 实测条带：
• 52kD

• 背景：
• The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012],

• 功能：
• alternative products:Additional isoforms seem to exist,disease:Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM:125850]; also shortened MODY-1. MODY [MIM:606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications.,function:Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.,miscellaneous:Binds fatty acids.,online information:Hepatocyte nuclear fac

• 细胞定位：
• Nucleus.

• 组织表达：
• Kidney,Liver,

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