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HDAC7 Polyclonal Antibody

货号：YT2119
应用：WB;ELISA
种属：Human;Mouse;Rat

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靶点：
HDAC7

简介：
>>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis

基因名称：
HDAC7

蛋白名称：
Histone deacetylase 7

Human Gene Id：
51564

Human Swiss Prot No：
Q8WUI4

Mouse Gene Id：
56233

Mouse Swiss Prot No：
Q8C2B3

Rat Swiss Prot No：
Q99P96

免疫原：
The antiserum was produced against synthesized peptide derived from human HDAC7A. AA range:121-170

特异性：
HDAC7 Polyclonal Antibody detects endogenous levels of HDAC7 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
HDAC7;HDAC7A;Histone deacetylase 7;HD7;Histone deacetylase 7A;HD7a

实测条带：
103kD

背景：
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

功能：
catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,domain:The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repres

细胞定位：
Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

组织表达：
B-cell,Cervix carcinoma,Colon,Embryo,Epithelium,Human lung,Placenta,Spleen,Teratoca

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货号：YT2119