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GROγ Polyclonal Antibody

货号：YT2075
应用：IHC;IF;ELISA
种属：Human;Rat;Mouse;

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靶点：
GROγ

简介：
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Alcoholic liver disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Legionellosis;>>Amoebiasis;>>Kaposi sarcoma-associated herpesvirus infection;>>Rheumatoid arthritis;>>Lipid and atherosclerosis

基因名称：
CXCL3

蛋白名称：
C-X-C motif chemokine 3

Human Gene Id：
2921

Human Swiss Prot No：
P19876

Mouse Swiss Prot No：
Q6W5C0

免疫原：
The antiserum was produced against synthesized peptide derived from human GROgamma. AA range:58-107

特异性：
GROγ Polyclonal Antibody detects endogenous levels of GROγ protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CXCL3;GRO3;GROG;SCYB3;C-X-C motif chemokine 3;GRO-gamma(1-73);Growth-regulated protein gamma;GRO-gamma;Macrophage inflammatory protein 2-beta;MIP2-beta

分子量：
11kD

背景：
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014],

功能：
function:Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.,online information:CXCL3 entry,PTM:N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

细胞定位：
Secreted.

组织表达：
Histiocytic lymphoma,Lung,Peripheral blood monocyte,Placenta,

CXCL3 overexpression promotes the tumorigenic potential of uterine cervical cancer cells via the MAPK/ERK pathway. JOURNAL OF CELLULAR PHYSIOLOGY J Cell Physiol. 2020 May;235(5):4756-4765 IHC Human uterine cervical tissue
货号：YT2075

CXCL3 overexpression affects the malignant behavior of oral squamous cell carcinoma cells via the MAPK signaling pathway. JOURNAL OF ORAL PATHOLOGY & MEDICINE J Oral Pathol Med. 2021 Oct;50(9):902-910 IHC Human Oral tissue
货号：YT2075

Clinical significance and biological functions of chemokine CXCL3 in head and neck squamous cell carcinoma. BIOSCIENCE REPORTS Bioscience Rep. 2021 Dec;():BSR20212403 IHC Human head , neck tissue
货号：YT2075

CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway Journal of Molecular Cell Biology Xiangyang Xiong IHC Human breast tissue,breast cancer tissue
货号：YT2075

Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions. Communications Biology Zhihong Liu IF Human 1:100 renal mesangial cells (MCs),retinal pericytes (RPCs)
货号：YT2075

Elevated expression of CXCL3 in colon cancer promotes malignant behaviors of tumor cells in an ERK-dependent manner BMC CANCER Cheng Yao IHC Human 1:100 colon tissue
货号：YT2075