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GROα Polyclonal Antibody

货号：YT2074
应用：IHC;IF;ELISA
种属：Human;Mouse;Rat

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靶点：
GROα

简介：
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Alcoholic liver disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Legionellosis;>>Amoebiasis;>>Kaposi sarcoma-associated herpesvirus infection;>>Rheumatoid arthritis;>>Lipid and atherosclerosis

基因名称：
CXCL1

蛋白名称：
Growth-regulated alpha protein

Human Gene Id：
2919

Human Swiss Prot No：
P09341

Mouse Gene Id：
14825

Mouse Swiss Prot No：
P12850

Rat Gene Id：
81503

Rat Swiss Prot No：
P14095

免疫原：
The antiserum was produced against synthesized peptide derived from human GROalpha. AA range:39-88

特异性：
GROα Polyclonal Antibody detects endogenous levels of GROα protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CXCL1;GRO;GRO1;GROA;MGSA;SCYB1;Growth-regulated alpha protein;C-X-C motif chemokine 1;GRO-alpha(1-73);Melanoma growth stimulatory activity;MGSA;Neutrophil-activating protein 3;NAP-3

分子量：
11kD

背景：
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014],

功能：
function:Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.,online information:CXCL1 entry,PTM:N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

细胞定位：
Secreted.

组织表达：
Blood,Ovary,Peripheral blood monocyte,Placenta,Skin,

High expression level of CXCL1/GROα is linked to advanced stage and worse survival in uterine cervical cancer and facilitates tumor cell malignant processes IHC Human 1:100 uterine cervical tissue/
货号：YT2074

Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop Discover Oncology Huang Wei IHC Human 1:100 oral squamous cell carcinoma (OSCC) tissue,epithelial tissue
货号：YT2074