• 靶点：
• GRB14

• 基因名称：
• GRB14

• 蛋白名称：
• Growth factor receptor-bound protein 14

• Human Gene Id：
• 2888

• Human Swiss Prot No：
• Q14449

• Mouse Gene Id：
• 50915

• Mouse Swiss Prot No：
• Q9JLM9

• Rat Gene Id：
• 58844

• Rat Swiss Prot No：
• O88900

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GRB14. AA range:81-130

• 特异性：
• GRB14 Polyclonal Antibody detects endogenous levels of GRB14 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GRB14;Growth factor receptor-bound protein 14;GRB14 adapter protein

• 实测条带：
• 61kD

• 背景：
• The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

• 功能：
• function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Binds to the ankyrin repeat region of TNKS2 via its N-terminus.,tissue specificity:Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.,

• 细胞定位：
• Cytoplasm . Endosome membrane ; Peripheral membrane protein . Upon insulin stimulation, translocates to the plasma membrane. .

• 组织表达：
• Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

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