• 靶点：
• Glucagon Receptor

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Glucagon signaling pathway

• 基因名称：
• GCGR

• 蛋白名称：
• Glucagon receptor

• Human Gene Id：
• 2642

• Human Swiss Prot No：
• P47871

• Mouse Gene Id：
• 14527

• Mouse Swiss Prot No：
• Q61606

• Rat Gene Id：
• 24953

• Rat Swiss Prot No：
• P30082

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GLR. AA range:95-144

• 特异性：
• Glucagon Receptor Polyclonal Antibody detects endogenous levels of Glucagon Receptor protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GCGR;Glucagon receptor;GL-R

• 实测条带：
• 54kD

• 背景：
• glucagon receptor(GCGR) Homo sapiens The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010],

• 功能：
• disease:It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.,function:This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Is rapidly internalized after ligand-binding. .

• 组织表达：
• Liver,Placenta,

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