• 靶点：
• GLP1R

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Insulin secretion

• 基因名称：
• GLP1R

• 蛋白名称：
• Glucagon-like peptide 1 receptor

• Human Gene Id：
• 2740

• Human Swiss Prot No：
• P43220

• Mouse Swiss Prot No：
• O35659

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GLP1R. AA range:101-150

• 特异性：
• GLP-1R Polyclonal Antibody detects endogenous levels of GLP-1R protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GLP1R;Glucagon-like peptide 1 receptor;GLP-1 receptor;GLP-1-R;GLP-1R

• 实测条带：
• 53kD

• 背景：
• glucagon like peptide 1 receptor(GLP1R) Homo sapiens This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016],

• 功能：
• function:This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,online information:Glucagon-like peptide 1 entry,similarity:Belongs to the G-protein coupled receptor 2 family.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Gastric carcinoma,Insulinoma,Pancreas,Pancreatic islet,Placenta,

Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo. JOURNAL OF DENTISTRY J Dent. 2020 Mar;94:103310 IF Human 1:2000 HPDLCs
货号：YT1916

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