GABAA Rβ2 Polyclonal Antibody
- 货号:YT1825
- 应用:WB;IHC;IF;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction
- 蛋白名称:
- Gamma-aminobutyric acid receptor subunit beta-2
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human GABAA Rbeta2. AA range:382-431
- 特异性:
- GABAA Rβ2 Polyclonal Antibody detects endogenous levels of GABAA Rβ2 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- GABRB2;Gamma-aminobutyric acid receptor subunit beta-2;GABA(A) receptor subunit beta-2
- 背景:
- The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008],
- 功能:
- function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.,
- 细胞定位:
- Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
- 组织表达:
- Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
![](/uploadfiles/PIC/yt1825-ihc-464.jpg)
- Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
![](/uploadfiles/PIC/yt1825_pic928918522.jpg)
- Immunohistochemistry analysis of GABAA Rβ2 antibody in paraffin-embedded human brain tissue.