• 靶点：
• FIR

• 简介：
• >>Rap1 signaling pathway;>>Adherens junction

• 基因名称：
• FARP2

• 蛋白名称：
• FERM RhoGEF and pleckstrin domain-containing protein 2

• Human Gene Id：
• 9855

• Human Swiss Prot No：
• O94887

• Mouse Gene Id：
• 227377

• Mouse Swiss Prot No：
• Q91VS8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human FIR. AA range:331-380

• 特异性：
• FIR Polyclonal Antibody detects endogenous levels of FIR protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FARP2;KIAA0793;PLEKHC3;FERM; RhoGEF and pleckstrin domain-containing protein 2;FERM domain including RhoGEF;FIR;Pleckstrin homology domain-containing family C member 3;PH domain-containing family C member 3

• 实测条带：
• 119kD

• 背景：
• function:Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 FERM domain.,similarity:Contains 2 PH domains.,subunit:Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding.,

• 功能：
• function:Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 FERM domain.,similarity:Contains 2 PH domains.,subunit:Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding.,

• 细胞定位：
• cytoplasm,cytosol,cytoskeleton,extrinsic component of membrane,

• 组织表达：
• Brain,Testis,

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