• 靶点：
• ELOVL4

• 简介：
• >>Fatty acid elongation;>>Biosynthesis of unsaturated fatty acids;>>Metabolic pathways;>>Fatty acid metabolism

• 基因名称：
• ELOVL4

• 蛋白名称：
• Elongation of very long chain fatty acids protein 4

• Human Gene Id：
• 6785

• Human Swiss Prot No：
• Q9GZR5

• Mouse Gene Id：
• 83603

• Mouse Swiss Prot No：
• Q9EQC4

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ELOVL4. AA range:41-90

• 特异性：
• ELOVL4 Polyclonal Antibody detects endogenous levels of ELOVL4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ELOVL4;Elongation of very long chain fatty acids protein 4;3-keto acyl-CoA synthase ELOVL4;ELOVL fatty acid elongase 4;ELOVL FA elongase 4

• 实测条带：
• 37kD

• 背景：
• This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in ELOVL4 are the cause of macular dystrophy autosomal dominant chromosome 6-linked (ADMD) [MIM:600110]. A form of macular degeneration characterized by decreased visual acuity, macular atrophy and extensive fundus flecks.,disease:Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3) [MIM:600110]. STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant.,domain:The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.,function:Involved in the biosynthesis of very long chain fatty acids. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing

• 细胞定位：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein .

• 组织表达：
• Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.

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