- 靶点:
- EDG-3
- 简介:
- >>Sphingolipid signaling pathway;>>Neuroactive ligand-receptor interaction
- 基因名称:
- S1PR3
- 蛋白名称:
- Sphingosine 1-phosphate receptor 3
- Human Gene Id:
- 1903
- Human Swiss Prot No:
- Q99500
- Mouse Gene Id:
- 13610
- Mouse Swiss Prot No:
- Q9Z0U9
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human EDG3. AA range:115-164
- 特异性:
- EDG-3 Polyclonal Antibody detects endogenous levels of EDG-3 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度:
- 1 mg/ml
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- S1PR3;EDG3;Sphingosine 1-phosphate receptor 3;S1P receptor 3;S1P3;Endothelial differentiation G-protein coupled receptor 3;Sphingosine 1-phosphate receptor Edg-3;S1P receptor Edg-3
- 实测条带:
- 42kD
- 背景:
- This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008],
- 功能:
- function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.,
- 细胞定位:
- Cell membrane; Multi-pass membrane protein.
- 组织表达:
- Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
Hyperglycemia‐Triggered Sphingosine‐1‐Phosphate and Sphingosine‐1‐Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization. LIVER TRANSPLANTATION Liver Transplant. 2019 Jul;25(7):1074-1090 WB Mouse 1:100 Liver
货号:YT1462
Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1. Frontiers in Pharmacology Front Pharmacol. 2021 May;0:1195 WB Mouse,Human Liver,serum exosomes
货号:YT1462
Yuan Chang, Hu, et al. "Hyperglycemia Triggered S1P/S1PR3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization." Chao and Yang, Shikun and Cheng, Xuyu and Cheng, Feng and Rao, Jianhua and Wang, Xue-Hao, Hyperglycemia Triggered S1P/S1PR3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M 1 (2018).
货号:YT1462
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- September 08-2020
- FLOW-CYTOMEYRT-PROTOCOL
- May 20-2022
- Cell-Based ELISA│解您多样本WB检测之困扰
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- Antibody-FAQs
- 产品图片
- Yuan Chang, Hu, et al. "Hyperglycemia Triggered S1P/S1PR3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization." Chao and Yang, Shikun and Cheng, Xuyu and Cheng, Feng and Rao, Jianhua and Wang, Xue-Hao, Hyperglycemia Triggered S1P/S1PR3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M 1 (2018).
- Western Blot analysis of HT-29 cells using EDG-3 Polyclonal Antibody
- Western blot analysis of lysates from HT-29 cells, using EDG3 Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HepG2 cells using EDG3 antibody.