• 靶点：
• Dynein LC 1

• 简介：
• >>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases

• 基因名称：
• DNAL1

• 蛋白名称：
• Dynein light chain 1 axonemal

• Human Gene Id：
• 83544

• Human Swiss Prot No：
• Q4LDG9

• Mouse Gene Id：
• 105000

• Mouse Swiss Prot No：
• Q05A62

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human DNAL1. AA range:121-170

• 特异性：
• Dynein LC 1 Polyclonal Antibody detects endogenous levels of Dynein LC 1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DNAL1;C14orf168;Dynein light chain 1; axonemal

• 实测条带：
• 22kD

• 背景：
• This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011],

• 功能：
• similarity:Belongs to the dynein light chain LC1-type family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with DNAH5.,tissue specificity:Expressed in tissues carrying motile cilia such as testis.,

• 细胞定位：
• Cytoplasm, cytoskeleton, cilium axoneme .

• 组织表达：
• Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.

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