• 靶点：
• DRS-1

• 简介：
• >>Fatty acid degradation;>>Peroxisome

• 基因名称：
• ECI2

• 蛋白名称：
• Enoyl-CoA delta isomerase 2 mitochondrial

• Human Gene Id：
• 10455

• Human Swiss Prot No：
• O75521

• Mouse Swiss Prot No：
• Q9WUR2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PECI. AA range:73-122

• 特异性：
• DRS-1 Polyclonal Antibody detects endogenous levels of DRS-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ECI2;DRS1;HCA88;PECI;Enoyl-CoA delta isomerase 2; mitochondrial;DRS-1;Delta(3),delta(2)-enoyl-CoA isomerase;D3,D2-enoyl-CoA isomerase;Diazepam-binding inhibitor-related protein 1;DBI-related protein 1;Dodecenoyl-CoA isomerase;Hep

• 实测条带：
• 40kD

• 背景：
• This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011],

• 功能：
• catalytic activity:(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.,function:Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.,similarity:Contains 1 ACB (acyl-CoA-binding) domain.,similarity:In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.,tissue specificity:Abundant in heart, skeletal muscle and liver.,

• 细胞定位：
• [Isoform 1]: Mitochondrion .; [Isoform 2]: Peroxisome matrix .

• 组织表达：
• Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.

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