DLC-1 Polyclonal Antibody
- 货号:YT1356
- 应用:IHC;IF;ELISA
- 种属:Human;Mouse;Rat
- 蛋白名称:
- Rho GTPase-activating protein 7
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human RHG07. AA range:61-110
- 特异性:
- DLC-1 Polyclonal Antibody detects endogenous levels of DLC-1 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- DLC1;ARHGAP7;KIAA1723;STARD12;Rho GTPase-activating protein 7;Deleted in liver cancer 1 protein;DLC-1;HP protein;Rho-type GTPase-activating protein 7;START domain-containing protein 12;StARD12;StAR-related lipid transfer protein
- 背景:
- This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010],
- 功能:
- function:Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization.,sequence caution:Chimera. Sequence from position 1 to 13 is due to a chimera.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 START domain.,tissue specificity:Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.,
- 细胞定位:
- Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
- 组织表达:
- Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.
![](/uploadfiles/PIC/yt1356_pic571218522.jpg)
- Immunofluorescence analysis of A549 cells, using RHG07 Antibody. The picture on the right is blocked with the synthesized peptide.
![](/uploadfiles/PIC/yt1356_pic571318522.jpg)
- Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using RHG07 Antibody. The picture on the right is blocked with the synthesized peptide.