• 靶点：
• Desmin

• 简介：
• >>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy

• 基因名称：
• DES

• 蛋白名称：
• Desmin

• Human Gene Id：
• 1674

• Human Swiss Prot No：
• P17661

• Mouse Gene Id：
• 13346

• Mouse Swiss Prot No：
• P31001

• Rat Gene Id：
• 64362

• Rat Swiss Prot No：
• P48675

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Desmin. AA range:421-470

• 特异性：
• Desmin Polyclonal Antibody detects endogenous levels of Desmin protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DES;Desmin

• 实测条带：
• 55kD

• 背景：
• This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM).,disease:Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400].

• 细胞定位：
• Cytoplasmic

• 组织表达：
• Muscle,Skeletal muscle,

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis. Nature Communications 2017 Apr 10 WB,IF Human,Mouse 1:1000 liver,SGC7901 cell-xenograft SGC7901 cell
货号：YT1326

MicroRNA-182 Regulates Neurite Outgrowth Involving the PTEN/AKT Pathway. Frontiers in Cellular Neuroscience 2017 Apr 10 WB,IF Mouse 1:1000 primary liver cell
货号：YT1326

The PI3K/p-Akt signaling pathway participates in calcitriol ameliorating podocyte injury in DN rats. METABOLISM-CLINICAL AND EXPERIMENTAL Metabolism. 2014 Oct;63:1324 WB Rat Renal tissues
货号：YT1326

Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice. Cell Death & Disease Cell Death Dis. 2018 Mar;9(3):1-15 WB Mouse podocytes
货号：YT1326

LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose‐induced podocyte injury via its interplay with β‐catenin. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2017 Apr 26 WB Mouse 1:1500 podocytes
货号：YT1326

PDGF-mediated PI3K/AKT/β-catenin signaling regulates gap junctions in corpus cavernosum smooth muscle cells. EXPERIMENTAL CELL RESEARCH Exp Cell Res. 2018 Jan;362:252 IF Rat 1:100 SMCs
货号：YT1326

Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro. Journal of Diabetes Research J Diabetes Res. 2016;2016:5671803 IF Mouse podocytes
货号：YT1326

Hu, Mengsi, et al. "Lnc RNA MALAT 1 is dysregulated in diabetic nephropathy and involved in high glucose‐induced podocyte injury via its interplay with β‐catenin." Journal of cellular and molecular medicine 21.11 (2017): 2732-2747.
货号：YT1326

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
• IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL

• June 19-2018
• IMMUNOFLUORESCENCE PROTOCOL

• September 08-2020
• FLOW-CYTOMEYRT-PROTOCOL

• May 20-2022
• Cell-Based ELISA│解您多样本WB检测之困扰

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN

• July 13-2018
• CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN

• July 13-2018
• Antibody-FAQs