• 靶点：
• CYP39A1

• 简介：
• >>Primary bile acid biosynthesis

• 基因名称：
• CYP39A1

• 蛋白名称：
• 24-hydroxycholesterol 7-alpha-hydroxylase

• Human Gene Id：
• 51302

• Human Swiss Prot No：
• Q9NYL5

• Mouse Swiss Prot No：
• Q9JKJ9

• 免疫原：
• Synthesized peptide derived from the Internal region of human CYP39A1.

• 特异性：
• CYP39A1 Polyclonal Antibody detects endogenous levels of CYP39A1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CYP39A1;24-hydroxycholesterol 7-alpha-hydroxylase;Cytochrome P450 39A1;hCYP39A1;Oxysterol 7-alpha-hydroxylase

• 实测条带：
• 55kD

• 背景：
• cytochrome P450 family 39 subfamily A member 1(CYP39A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

• 功能：
• catalytic activity:(24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) = (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Liver specific.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .

• 组织表达：
• Liver specific.

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