• 靶点：
• CYP2C19

• 简介：
• >>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>Serotonergic synapse;>>Chemical carcinogenesis - DNA adducts

• 基因名称：
• CYP2C19

• 蛋白名称：
• Cytochrome P450 2C19

• Human Gene Id：
• 1557

• Human Swiss Prot No：
• P33261

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2C19. AA range:241-290

• 特异性：
• CYP2C19 Polyclonal Antibody detects endogenous levels of CYP2C19 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CYP2C19;Cytochrome P450 2C19;(R)-limonene 6-monooxygenase;(S)-limonene 6-monooxygenase;(S)-limonene 7-monooxygenase;CYPIIC17;CYPIIC19;Cytochrome P450-11A;Cytochrome P450-254C;Mephenytoin 4-hydroxylase

• 实测条带：
• 56kD

• 背景：
• cytochrome P450 family 2 subfamily C member 19(CYP2C19) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:(+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O.,catalytic activity:(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.,catalytic activity:(-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O.,caution:P450-254C was originally listed as a separate gene (CYP2C17). Resequencing demonstrated that it is not a separate gene, but a chimera. The 5'-portion corresponds to a partial 2C18 clone, and the 3'-portion corresponds to a partial 2C19 clone.,cofactor:Heme group.,function:Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.,induction:P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carc

• 细胞定位：
• Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

• 组织表达：
• Liver,

Differentiation of umbilical cord mesenchymal stem cells into hepatocytes with CYP450 metabolic enzyme activity induced by a liver injury microenvironment BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Jinxuan Wang WB Human Umbilical cord mesenchymal stem cells (UCMSCs)
货号：YT1210

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