• 靶点：
• CYP2A6

• 简介：
• >>Caffeine metabolism;>>Retinol metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Chemical carcinogenesis - DNA adducts;>>Lipid and atherosclerosis

• 基因名称：
• CYP2A6

• 蛋白名称：
• Cytochrome P450 2A6

• Human Gene Id：
• 1548

• Human Swiss Prot No：
• P11509

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2A6. AA range:1-50

• 特异性：
• CYP2A6 Polyclonal Antibody detects endogenous levels of CYP2A6 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CYP2A6;CYP2A3;Cytochrome P450 2A6;1;4-cineole 2-exo-monooxygenase;CYPIIA6;Coumarin 7-hydroxylase;Cytochrome P450 IIA3;Cytochrome P450(I)

• 实测条带：
• 56kD

• 背景：
• This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase.,induction:By phenobarbital and dexamethasone.,online information:CYP2A6 alleles,online information:CYP2A6 entry,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Liver.,

• 细胞定位：
• Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

• 组织表达：
• Liver.

High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. Frontiers in Pharmacology Front Pharmacol. 2017 May;8:233 WB Human 1:200 HepG2 cell
货号：YT1204

Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification. Frontiers in Pharmacology Front Pharmacol. 2018 May;0:554 WB Chicken 1:200 liver tissues
货号：YT1204

Differentiation of umbilical cord mesenchymal stem cells into hepatocytes with CYP450 metabolic enzyme activity induced by a liver injury microenvironment BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Jinxuan Wang WB Human Umbilical cord mesenchymal stem cells (UCMSCs)
货号：YT1204

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