• 靶点：
• Cyclin A

• 简介：
• >>Cell cycle;>>AMPK signaling pathway;>>Cellular senescence;>>Progesterone-mediated oocyte maturation;>>Hepatitis B;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Viral carcinogenesis;>>Acute myeloid leukemia

• 基因名称：
• CCNA1

• 蛋白名称：
• Cyclin-A1

• Human Gene Id：
• 8900

• Human Swiss Prot No：
• P78396

• Mouse Gene Id：
• 12427

• Mouse Swiss Prot No：
• Q61456

• Rat Gene Id：
• 295052

• Rat Swiss Prot No：
• Q6AY13

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Cyclin A1. AA range:411-460

• 特异性：
• Cyclin A1 Polyclonal Antibody detects endogenous levels of Cyclin A1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CCNA1;Cyclin-A1

• 实测条带：
• 52kD

• 背景：
• The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multi

• 功能：
• developmental stage:Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.,function:May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin AB subfamily.,subunit:Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9.,tissue specificit

• 细胞定位：
• Nucleus .

• 组织表达：
• Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 2016 Dec 01 WB Human U2OS cell
货号：YT1168

CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells. ONCOLOGY REPORTS 2017 Dec 04 WB Human 1:1000 Saos-2 cell
货号：YT1168

潘晓菲, et al. "长链非编码 RNA CTB-147C22. 8 对复发性呼吸道乳头状瘤上皮细胞内蛋白表达的影响." 中国耳鼻咽喉头颈外科 27.3 (2021): 171.
货号：YT1168

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