• 靶点：
• CSP

• 简介：
• >>Protein processing in endoplasmic reticulum

• 基因名称：
• DNAJC5

• 蛋白名称：
• DnaJ homolog subfamily C member 5

• Human Gene Id：
• 80331

• Human Swiss Prot No：
• Q9H3Z4

• Mouse Gene Id：
• 13002

• Mouse Swiss Prot No：
• P60904

• Rat Gene Id：
• 79130

• Rat Swiss Prot No：
• P60905

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human DNAJC5. AA range:131-180

• 特异性：
• CSP Polyclonal Antibody detects endogenous levels of CSP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DNAJC5;CSP;DnaJ homolog subfamily C member 5;Cysteine string protein;CSP

• 实测条带：
• 30kD

• 背景：
• This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010],

• 功能：
• function:May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,similarity:Contains 1 J domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.,

• 细胞定位：
• Cytoplasm, cytosol . Membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane . Melanosome . Cell membrane . The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

• 组织表达：
• Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.

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