• 靶点：
• c-Rel

• 简介：
• >>Ras signaling pathway;>>Transcriptional misregulation in cancer;>>Viral carcinogenesis

• 基因名称：
• REL

• 蛋白名称：
• Proto-oncogene c-Rel

• Human Gene Id：
• 5966

• Human Swiss Prot No：
• Q04864

• Mouse Swiss Prot No：
• P15307

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Rel. AA range:470-519

• 特异性：
• c-Rel Polyclonal Antibody detects endogenous levels of c-Rel protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• REL;Proto-oncogene c-Rel

• 实测条带：
• 68kD

• 背景：
• This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],

• 功能：
• function:Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as b

• 细胞定位：
• Nucleus .

• 组织表达：
• Colon,

The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2017 Nov;51(5):1497-1507 WB Human 1:1000 cervical cancer tissues CaSki cell
货号：YT1105

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