• 靶点：
• COX17

• 简介：
• >>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis

• 基因名称：
• COX17

• 蛋白名称：
• Cytochrome c oxidase copper chaperone

• Human Gene Id：
• 10063

• Human Swiss Prot No：
• Q14061

• Mouse Gene Id：
• 12856

• Mouse Swiss Prot No：
• P56394

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human COX17. AA range:1-50

• 特异性：
• COX17 Polyclonal Antibody detects endogenous levels of COX17 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• COX17;Cytochrome c oxidase copper chaperone

• 实测条带：
• 7kD

• 背景：
• Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provi

• 功能：
• function:Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.,similarity:Belongs to the COX17 family.,tissue specificity:Ubiquitous.,

• 细胞定位：
• Mitochondrion intermembrane space . Cytoplasm .

• 组织表达：
• Ubiquitous.

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