• 靶点：
• Connexin 46

• 基因名称：
• GJA3

• 蛋白名称：
• Gap junction alpha-3 protein

• Human Gene Id：
• 2700

• Human Swiss Prot No：
• Q9Y6H8

• Mouse Gene Id：
• 14611

• Mouse Swiss Prot No：
• Q64448

• Rat Gene Id：
• 79217

• Rat Swiss Prot No：
• P29414

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GJA3. AA range:151-200

• 特异性：
• Connexin 46 Polyclonal Antibody detects endogenous levels of Connexin 46 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GJA3;Gap junction alpha-3 protein;Connexin-46;Cx46

• 分子量：
• 47kD

• 背景：
• The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010],

• 功能：
• disease:Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. CZP3 is a form of autosomal dominant congenital cataract.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Alpha-type (group II) subfamily.,subunit:A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .

• 组织表达：
• Lens fibers,

Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment. Cells2022 Jan;11(7):1196. Rat lens epithelial cells
货号：YT1048

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