• 靶点：
• CLP36

• 基因名称：
• PDLIM1

• 蛋白名称：
• PDZ and LIM domain protein 1

• Human Gene Id：
• 9124

• Human Swiss Prot No：
• O00151

• Mouse Gene Id：
• 54132

• Mouse Swiss Prot No：
• O70400

• Rat Gene Id：
• 54133

• Rat Swiss Prot No：
• P52944

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PDLIM1. AA range:61-110

• 特异性：
• CLP36 Polyclonal Antibody detects endogenous levels of CLP36 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PDLIM1;CLIM1;CLP36;PDZ and LIM domain protein 1;C-terminal LIM domain protein 1;Elfin;LIM domain protein CLP-36

• 实测条带：
• 36kD

• 背景：
• This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012],

• 功能：
• function:Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Associates with the actin stress fibers.,subunit:Interacts with alpha-actinins 1, 2 and 4.,tissue specificity:Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.,

• 细胞定位：
• Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Associates with actin stress fibers. .

• 组织表达：
• Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.

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