• 靶点：
• Claudin-4

• 简介：
• >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C

• 基因名称：
• CLDN4

• 蛋白名称：
• Claudin-4

• Human Gene Id：
• 1364

• Human Swiss Prot No：
• O14493

• Mouse Gene Id：
• 12740

• Mouse Swiss Prot No：
• O35054

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Claudin 4. AA range:160-209

• 特异性：
• Claudin-4 Polyclonal Antibody detects endogenous levels of Claudin-4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CLDN4;CPER;CPETR1;WBSCR8;Claudin-4;Clostridium perfringens enterotoxin receptor;CPE-R;CPE-receptor;Williams-Beuren syndrome chromosomal region 8 protein

• 实测条带：
• 22kD

• 背景：
• The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013],

• 功能：
• disease:Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,

• 细胞定位：
• Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . CLDN4 is required for tight junction localization in the kidney. .

• 组织表达：
• Colon,Fetal brain,Trachea,

Changes in intestinal barrier protein expression and intestinal flora in a rat model of visceral hypersensitivity. NEUROGASTROENTEROLOGY AND MOTILITY 2021 Nov 25 WB Rat 1:1000 Colon tissue
货号：YT0951

Changes in the Gut Microbiome Contribute to the Development of Behcet’s Disease via Adjuvant Effects. Frontiers in Cell and Developmental Biology Front Cell Dev Biol. 2021 Sep;0:2482 WB Mouse 1:1000 Colon
货号：YT0951

Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice. Food & Function Food Funct. 2020 Apr;11(4):3167-3179 WB Mouse 1:2000 ileal tissues
货号：yT0951

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