• 靶点：
• CDX2

• 简介：
• >>Gastric cancer

• 基因名称：
• CDX2

• 蛋白名称：
• Homeobox protein CDX-2

• Human Gene Id：
• 1045

• Human Swiss Prot No：
• Q99626

• Mouse Gene Id：
• 12591

• Mouse Swiss Prot No：
• P43241

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CDX2. AA range:249-298

• 特异性：
• Cdx2 Polyclonal Antibody detects endogenous levels of Cdx2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CDX2;CDX3;Homeobox protein CDX-2;CDX-3;Caudal-type homeobox protein 2

• 实测条带：
• 45kD

• 背景：
• This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],

• 功能：
• function:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Detected in small intestine, colon and pancreas.

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