• 靶点：
• CD34

• 简介：
• >>Cell adhesion molecules;>>Hematopoietic cell lineage

• 基因名称：
• CD34

• 蛋白名称：
• Hematopoietic progenitor cell antigen CD34

• Human Gene Id：
• 947

• Human Swiss Prot No：
• P28906

• Mouse Gene Id：
• 12490

• Mouse Swiss Prot No：
• Q64314

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CD34. AA range:208-257

• 特异性：
• CD34 Polyclonal Antibody detects endogenous levels of CD34 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD34;Hematopoietic progenitor cell antigen CD34;CD antigen CD34

• 实测条带：
• 110kD

• 背景：
• The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

• 功能：
• alternative products:Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation,developmental stage:On early hematopoietic progenitor cells.,disease:Abnormal CD34 expression in leukemogenesis.,function:Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.,online information:CD34 entry,PTM:Highly glycosylated.,PTM:Phosphorylated on serine residues by PKC.,similarity:Belongs to the CD34 family.,tissue specificity:Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tiss

• 细胞定位：
• Membrane; Single-pass type I membrane protein.

• 组织表达：
• Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

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A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan. Acta Biomaterialia Acta Biomater. 2016 Feb;31:186 IF Mouse 4T1 tumor
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