• 靶点：
• CCK-AR

• 简介：
• >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Insulin secretion;>>Pancreatic secretion

• 基因名称：
• CCKAR

• 蛋白名称：
• Cholecystokinin receptor type A

• Human Gene Id：
• 886

• Human Swiss Prot No：
• P32238

• Mouse Gene Id：
• 12425

• Mouse Swiss Prot No：
• O08786

• Rat Gene Id：
• 24889

• Rat Swiss Prot No：
• P30551

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CCKAR. AA range:215-264

• 特异性：
• CCK-AR Polyclonal Antibody detects endogenous levels of CCK-AR protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CCKAR;CCKRA;Cholecystokinin receptor type A;CCK-A receptor;CCK-AR;Cholecystokinin-1 receptor;CCK1-R

• 实测条带：
• 44kD

• 背景：
• This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008],

• 功能：
• function:Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Cholecystokinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Gall bladder,Peripheral blood leukocyte,Stomach,

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