• 靶点：
• CBP80

• 简介：
• >>Nucleocytoplasmic transport;>>mRNA surveillance pathway;>>Spliceosome;>>Amyotrophic lateral sclerosis

• 基因名称：
• NCBP1

• 蛋白名称：
• Nuclear cap-binding protein subunit 1

• Human Gene Id：
• 4686

• Human Swiss Prot No：
• Q09161

• Mouse Gene Id：
• 433702

• Mouse Swiss Prot No：
• Q3UYV9

• Rat Gene Id：
• 298075

• Rat Swiss Prot No：
• Q56A27

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human NCBP1. AA range:1-50

• 特异性：
• CBP80 Polyclonal Antibody detects endogenous levels of CBP80 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NCBP1;CBP80;NCBP;Nuclear cap-binding protein subunit 1;80 kDa nuclear cap-binding protein;CBP80;NCBP 80 kDa subunit

• 实测条带：
• 80kD

• 背景：
• The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008],

• 功能：
• function:Involved in mediating U snRNA export from the nucleus. Binds to 5' capped mRNA.,similarity:Belongs to the NCBP1 family.,similarity:Contains 1 MIF4G domain.,subunit:Found in a U snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX (By similarity). Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2.,

• 细胞定位：
• Nucleus . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .

• 组织表达：
• Brain,Epithelium,Placenta,

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