ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

Caspase12 Polyclonal Antibody

货号：YT0654
应用：WB;IHC;IF;ELISA
种属：Human;Rat;Mouse;

产品详情
文献 ( 4 )
操作手册

靶点：
Caspase-12

简介：
>>Protein processing in endoplasmic reticulum;>>Apoptosis;>>NOD-like receptor signaling pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Hepatitis B

基因名称：
CASP12

蛋白名称：
caspase12

Human Gene Id：
120329

Human Swiss Prot No：
Q6UXS9

Mouse Swiss Prot No：
O08736

免疫原：
The antiserum was produced against synthesized peptide derived from human Caspase12. AA range:50-99

特异性：
Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CASP12;Inactive caspase-12;CASP-12

实测条带：
50kD

背景：
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011],

功能：
proteolysis, apoptosis, virus-infected cell apoptosis, ER-nuclear signaling pathway, response to unfolded protein, cell death, response to organic substance, regulation of cell death, programmed cell death, death, endoplasmic reticulum unfolded protein response, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of apoptosis, regulation of programmed cell death, response to protein stimulus,apoptosis in response to endoplasmic reticulum stress,

细胞定位：
endoplasmic reticulum,IPAF inflammasome complex,NLRP3 inflammasome complex,AIM2 inflammasome complex,

组织表达：
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.

Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity. Frontiers in Pharmacology Front Pharmacol. 2021 Aug;0:1609 WB Mouse 1:2000 A549 cell-xenograft
货号：YT0654

Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE‐PDT in MG63 cells. Cancer Medicine 2016 Oct 03 WB Human MG63 cell
货号：YT0654

Endoplasmic reticulum stress plays an important role in methotrexate-related cognitive impairment in adult rats. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2017; 10(10): 10252–10260 WB Rat 1:100 hippocampal tissues
货号：YT0654

Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE‐PDT in MG63 cells. Cancer Medicine 2016 Oct 03 WB Human MG63 cell
货号：YT0654