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Calpain 11 Polyclonal Antibody

货号：YT0615
应用：WB;ELISA
种属：Human;Rat;Mouse;

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靶点：
Calpain 11

基因名称：
CAPN11

蛋白名称：
Calpain-11

Human Gene Id：
11131

Human Swiss Prot No：
Q9UMQ6

Mouse Swiss Prot No：
Q6J756

免疫原：
The antiserum was produced against synthesized peptide derived from human CAPN11. AA range:401-450

特异性：
Calpain 11 Polyclonal Antibody detects endogenous levels of Calpain 11 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CAPN11;Calpain-11;Calcium-activated neutral proteinase 11;CANP 11

实测条带：
81kD

背景：
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008],

功能：
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit.,tissue specificity:Highest expression in testis.,

细胞定位：
Cytoplasmic vesicle, secretory vesicle, acrosome .

组织表达：
Highest expression in testis.

3, 3'-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry." International Journal of Biological Sciences 17.5 (2021): 1217.
货号：YT0615