• 靶点：
• C/EBP β

• 简介：
• >>IL-17 signaling pathway;>>TNF signaling pathway;>>Tuberculosis;>>Transcriptional misregulation in cancer

• 基因名称：
• CEBPB

• 蛋白名称：
• CCAAT/enhancer-binding protein beta

• Human Gene Id：
• 1051

• Human Swiss Prot No：
• P17676

• Mouse Gene Id：
• 12608

• Mouse Swiss Prot No：
• P28033

• Rat Gene Id：
• 24253

• Rat Swiss Prot No：
• P21272

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human C/EBP-beta. AA range:201-250

• 特异性：
• C/EBP β Polyclonal Antibody detects endogenous levels of C/EBP β protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CEBPB;LAP;TCF5;PP9092;CCAAT/enhancer-binding protein beta;C/EBP beta;Liver activator protein;Nuclear factor NF-IL6;Transcription factor 5;TCF-5

• 实测条带：
• 36kD

• 背景：
• This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013],

• 功能：
• function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'.,PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2.,tissue specificity:Expressed at low levels in the lung, kidney and spleen.,

• 细胞定位：
• Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). .

• 组织表达：
• Expressed at low levels in the lung, kidney and spleen.

The C/EBPβ-Dependent Induction of TFDP2 Facilitates Porcine Reproductive and Respiratory Syndrome Virus Proliferation. VIROLOGICA SINICA Virol Sin. 2021 Dec;36(6):1341-1351 WB Pig 1:1000 3D4/21 cells
货号：YT0553

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