• 靶点：
• BTR1

• 基因名称：
• SLC4A11

• 蛋白名称：
• Sodium bicarbonate transporter-like protein 11

• Human Gene Id：
• 83959

• Human Swiss Prot No：
• Q8NBS3

• Mouse Swiss Prot No：
• A2AJN7

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human SLC4A11. AA range:291-340

• 特异性：
• BTR1 Polyclonal Antibody detects endogenous levels of BTR1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SLC4A11;BTR1;Sodium bicarbonate transporter-like protein 11;Bicarbonate transporter-related protein 1;Sodium borate cotransporter 1;NaBC1;Solute carrier family 4 member 11

• 实测条带：
• 100kD

• 背景：
• This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],

• 功能：
• disease:Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD) [MIM:217400]; also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive.,disease:Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700]; also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.,function:Transporter involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.,PTM:Glycosylated.,similarity:Belongs to the anion exchanger (TC

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes. ; [Isoform 3]: Expressed in corneal endothelium (at protein level). ; [Isoform 5]: The predominant isoform in corneal endothelium (at protein level).

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