BRCAA1 Polyclonal Antibody
- 货号:YT0521
- 应用:WB;ELISA
- 种属:Human;Mouse;Rat
- 蛋白名称:
- AT-rich interactive domain-containing protein 4B
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human BRCAA1. AA range:761-810
- 特异性:
- BRCAA1 Polyclonal Antibody detects endogenous levels of BRCAA1 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- ARID4B;BRCAA1;RBBP1L1;RBP1L1;SAP180;AT-rich interactive domain-containing protein 4B;ARID domain-containing protein 4B;180 kDa Sin3-associated polypeptide;Sin3-associated polypeptide p180;Breast cancer-associated antigen BRCAA1;Hi
- 背景:
- This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],
- 功能:
- domain:The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.,domain:The C-terminus mediates interaction with mSin3A corepressor complex.,domain:The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Contains 1 ARID domain.,subcellular location:Cytoplasmic in breast cancer cells.,subunit:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.,tissue specificity:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.,
- 细胞定位:
- Nucleus . Cytoplasm . Cytoplasmic in breast cancer cells. .
- 组织表达:
- Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
![](/uploadfiles/PIC/yt0521-wb.jpg)
- Western Blot analysis of various cells using BRCAA1 Polyclonal Antibody
![](/uploadfiles/PIC/yt0521_pic919418522.jpg)
- Western blot analysis of lysate from HUVEC cells, using BRCAA1 antibody.