BMP-3A Polyclonal Antibody
- 货号：YT0500
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 简介：
- >>Cytokine-cytokine receptor interaction
- 蛋白名称：
- Bone morphogenetic protein 3
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human BMP3. AA range:281-330
- 特异性：
- BMP-3A Polyclonal Antibody detects endogenous levels of BMP-3A protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- BMP3;BMP3A;Bone morphogenetic protein 3;BMP-3;Bone morphogenetic protein 3A;BMP-3A;Osteogenin
- 背景：
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],
- 功能：
- function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage.,
- 组织表达：
- Expressed in adult and fetal cartilage.
- Western Blot analysis of various cells using BMP-3A Polyclonal Antibody
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- Western Blot analysis of HepG2 cells using BMP-3A Polyclonal Antibody
- Western blot analysis of the lysates from HeLa cells using BMP3 antibody.
