• 靶点：
• ATF-3

• 基因名称：
• ATF3

• 蛋白名称：
• Cyclic AMP-dependent transcription factor ATF-3

• Human Gene Id：
• 467

• Human Swiss Prot No：
• P18847

• Mouse Gene Id：
• 11910

• Mouse Swiss Prot No：
• Q60765

• Rat Gene Id：
• 25389

• Rat Swiss Prot No：
• P29596

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ATF3. AA range:131-180

• 特异性：
• ATF-3 Polyclonal Antibody detects endogenous levels of ATF-3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ATF3;Cyclic AMP-dependent transcription factor ATF-3;cAMP-dependent transcription factor ATF-3;Activating transcription factor 3

• 实测条带：
• 21kD

• 背景：
• activating transcription factor 3(ATF3) Homo sapiens This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011],

• 功能：
• function:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a homodimer or a heterodimer.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Amygdala,Brain,Cerebellum,Muscle,

Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway. PHYTOMEDICINE Phytomedicine. 2021 Aug;89:153599 WB，IF Human 1 : 200，1:1000 Lung A549 cell
货号：YT0387

Wang, Zhichao, et al. "Citrus alkaline extract prevents endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway." Phytomedicine (2021): 153599.
货号：YT0387

Development and Validation of Robust Ferroptosis-Related Genes in Myocardial Ischemia-Reperfusion Injury. Journal of Cardiovascular Development and Disease Yu Liu IHC Mouse 1:250 hearts
货号：YT0387

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