• 靶点：
• APC5

• 简介：
• >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>IL-17 signaling pathway;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection

• 基因名称：
• ANAPC5

• 蛋白名称：
• Anaphase-promoting complex subunit 5

• Human Gene Id：
• 51433

• Human Swiss Prot No：
• Q9UJX4

• Mouse Swiss Prot No：
• Q8BTZ4

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200

• 特异性：
• APC5 Polyclonal Antibody detects endogenous levels of APC5 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ANAPC5;APC5;Anaphase-promoting complex subunit 5;APC5;Cyclosome subunit 5

• 实测条带：
• 85kD

• 背景：
• This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],

• 功能：
• function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,

• 细胞定位：
• Nucleus . Cytoplasm, cytoskeleton, spindle .

• 组织表达：
• Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga

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