• 靶点：
• ABHD12

• 基因名称：
• ABHD12

• 蛋白名称：
• Monoacylglycerol lipase ABHD12

• Human Gene Id：
• 26090

• Human Swiss Prot No：
• Q8N2K0

• Mouse Gene Id：
• 76192

• Mouse Swiss Prot No：
• Q99LR1

• Rat Gene Id：
• 499913

• Rat Swiss Prot No：
• Q6AYT7

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ABHD12. AA range:231-280

• 特异性：
• ABHD12 Polyclonal Antibody detects endogenous levels of ABHD12 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ABHD12;C20orf22;Monoacylglycerol lipase ABHD12;2-arachidonoylglycerol hydrolase;Abhydrolase domain-containing protein 12

• 实测条带：
• 45kD

• 背景：
• This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011],

• 功能：
• catalytic activity:Hydrolyzes glycerol monoesters of long-chain fatty acids.,function:Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways.,PTM:Glycosylated.,similarity:Belongs to the serine esterase family.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Single-pass membrane protein .

• 组织表达：
• Cerebellum,Kidney,Ovarian carcinoma,Pancreas,Testis,

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