• 靶点：
• eEF2

• 简介：
• >>AMPK signaling pathway;>>Oxytocin signaling pathway

• 基因名称：
• EEF2 EF2

• 蛋白名称：
• Elongation factor 2 (EF-2)

• Human Gene Id：
• 1938

• Human Swiss Prot No：
• P13639

• Mouse Gene Id：
• 13629

• Mouse Swiss Prot No：
• P58252

• Rat Gene Id：
• 29565

• Rat Swiss Prot No：
• P05197

• 免疫原：
• Synthesized phospho derived from human eEF2 (Phospho-Thr56)

• 特异性：
• This detects endogenous levels of eEF2 (Phospho-Thr56)

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000, ELISA 1:10000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Elongation factor 2 (EF-2)

• 实测条带：
• 100kD

• 背景：
• This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008],

• 功能：
• function:This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.,PTM:Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A.,PTM:Phosphorylation by EF-2 kinase completely inactivates EF-2.,similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.,subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.,

• 细胞定位：
• Cytoplasm . Nucleus . Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. .

• 组织表达：
• Brain,Cajal-Retzius cell,Epithelium,Hepatocyte,Ovary,Periph

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