• 靶点：
• Synapsin I

• 基因名称：
• SYN1

• 蛋白名称：
• Synapsin-1

• Human Gene Id：
• 6853

• Human Swiss Prot No：
• P17600

• Mouse Gene Id：
• 20964

• Mouse Swiss Prot No：
• O88935

• Rat Gene Id：
• 24949

• Rat Swiss Prot No：
• P09951

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Synapsin1 around the phosphorylation site of Ser605. AA range:576-625

• 特异性：
• Phospho-Synapsin I (S605) Polyclonal Antibody detects endogenous levels of Synapsin I protein only when phosphorylated at S605.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SYN1;Synapsin-1;Brain protein 4.1;Synapsin I

• 分子量：
• 74kD

• 背景：
• This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.,function:Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.,PTM:Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the synapsin family.,subunit:Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with

• 细胞定位：
• Cell junction, synapse. Golgi apparatus .

• 组织表达：
• Brain,Brain cortex,

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