• 靶点：
• Ets-1

• 简介：
• >>Ras signaling pathway;>>Cellular senescence;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Renal cell carcinoma

• 基因名称：
• ETS1

• 蛋白名称：
• Protein C-ets-1

• Human Gene Id：
• 2113

• Human Swiss Prot No：
• P14921

• Mouse Gene Id：
• 23871

• Mouse Swiss Prot No：
• P27577

• Rat Gene Id：
• 24356

• Rat Swiss Prot No：
• P41156

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ETS1 around the phosphorylation site of Thr38. AA range:11-60

• 特异性：
• Phospho-Ets-1 (T38) Polyclonal Antibody detects endogenous levels of Ets-1 protein only when phosphorylated at T38.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ETS1;EWSR2;Protein C-ets-1;p54

• 实测条带：
• 54kD

• 背景：
• This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],

• 功能：
• disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I.,

• 细胞定位：
• Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .

• 组织表达：
• Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nature Chemical Biology Nat Chem Biol. 2014 Sep;10(10):853-860 WB Human MDA-MB-231 breast cancer cell
货号：YP0878

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