• 靶点：
• TF

• 简介：
• >>Complement and coagulation cascades;>>AGE-RAGE signaling pathway in diabetic complications

• 基因名称：
• F3

• 蛋白名称：
• Tissue factor

• Human Gene Id：
• 2152

• Human Swiss Prot No：
• P13726

• Mouse Swiss Prot No：
• P20352

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Coagulation Factor III around the phosphorylation site of Ser290. AA range:246-295

• 特异性：
• Phospho-TF (S290) Polyclonal Antibody detects endogenous levels of TF protein only when phosphorylated at S290.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• F3;Tissue factor;TF;Coagulation factor III;Thromboplastin;CD antigen CD142

• 实测条带：
• 40kD

• 背景：
• This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

• 功能：
• function:Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.,induction:TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.,online information:The Singapore human mutation and polymorphism database,online information:Tissue factor entry,similarity:Belongs to the tissue factor family.,

• 细胞定位：
• [Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

• 组织表达：
• Lung, placenta and pancreas.

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