• 靶点：
• p62 Dok

• 基因名称：
• DOK1

• 蛋白名称：
• Docking protein 1

• Human Gene Id：
• 1796

• Human Swiss Prot No：
• Q99704

• Mouse Gene Id：
• 13448

• Mouse Swiss Prot No：
• P97465

• Rat Gene Id：
• 312477

• Rat Swiss Prot No：
• Q4QQV2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human p62 Dok around the phosphorylation site of Tyr398. AA range:365-414

• 特异性：
• Phospho-Dok-1 (Y398) Polyclonal Antibody detects endogenous levels of Dok-1 protein only when phosphorylated at Y398.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DOK1;Docking protein 1;Downstream of tyrosine kinase 1;p62(dok);pp62

• 实测条带：
• 62kD

• 背景：
• docking protein 1(DOK1) Homo sapiens The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016],

• 功能：
• domain:The PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.,PTM:Constitutively tyrosine-phosphorylated.,PTM:Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.,similarity:Belongs to the DOK family. Type A subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts with ABL (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3.,tissue specificity:Expressed in pancreas, heart, leukocyte and spleen

• 细胞定位：
• [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm, perinuclear region.

• 组织表达：
• Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.

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