• 靶点：
• CACNG2

• 简介：
• >>MAPK signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Oxytocin signaling pathway;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy

• 基因名称：
• CACNG2

• 蛋白名称：
• Voltage-dependent calcium channel gamma-2 subunit

• Human Gene Id：
• 10369

• Human Swiss Prot No：
• Q9Y698

• Mouse Swiss Prot No：
• O88602

• Rat Swiss Prot No：
• Q71RJ2

• 免疫原：
• Synthetic Peptide of CACNG2 AA range: 58-108

• 特异性：
• The antibody detects endogenous CACNG2 protein.

• 组成：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000 IHC 1:200-500. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Voltage-dependent calcium channel gamma-2 subunit;Neuronal voltage-gated calcium channel gamma-2 subunit;Transmembrane AMPAR regulatory protein gamma-2;TARP gamma-2

• 实测条带：
• 36kD

• 背景：
• calcium voltage-gated channel auxiliary subunit gamma 2(CACNG2) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010],

• 功能：
• function:Thought to stabilize the calcium channel in an inactivated (closed) state.,PTM:Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC.,tissue specificity:Brain.,

• 细胞定位：
• Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome .

• 组织表达：
• Brain.

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