CACNG2 Polyclonal Antibody
- 货号:YN5652
- 应用:WB;IHC;IF
- 种属:Human;Mouse;Rat
- 简介:
- >>MAPK signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Oxytocin signaling pathway;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
- 蛋白名称:
- Voltage-dependent calcium channel gamma-2 subunit
- 免疫原:
- Synthetic Peptide of CACNG2 AA range: 58-108
- 特异性:
- The antibody detects endogenous CACNG2 protein.
- 组成:
- PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:1000-2000 IHC 1:200-500. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Voltage-dependent calcium channel gamma-2 subunit;Neuronal voltage-gated calcium channel gamma-2 subunit;Transmembrane AMPAR regulatory protein gamma-2;TARP gamma-2
- 背景:
- calcium voltage-gated channel auxiliary subunit gamma 2(CACNG2) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010],
- 功能:
- function:Thought to stabilize the calcium channel in an inactivated (closed) state.,PTM:Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC.,tissue specificity:Brain.,
- 细胞定位:
- Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome .
![](/uploadfiles/PIC/ym3399-wb.jpg)
- Western blot analysis of 1) Human Brain Tissue, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using CACNG2 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
![](/uploadfiles/PIC/ym3399-ihc.jpg)
- Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using CACNG2 Polyclonal Antibody.