• 靶点：
• KCNN4

• 简介：
• >>Insulin secretion;>>GnRH secretion;>>Salivary secretion;>>Protein digestion and absorption

• 基因名称：
• KCNN4

• 蛋白名称：
• Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)

• Human Gene Id：
• 3783

• Human Swiss Prot No：
• O15554

• Mouse Swiss Prot No：
• O89109

• Rat Swiss Prot No：
• Q9QYW1

• 免疫原：
• Synthetic Peptide of KCNN4 (SK4) AA range: 177-227

• 特异性：
• KCNN4(SK4) protein(A247) detects endogenous levels of KCNN4(SK4)

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000, IHC 1:50-100. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• KCNN4;IK1;IKCA1;KCA4;SK4;Intermediate conductance calcium-activated potassium channel protein 4;SK4;SKCa 4;SKCa4;IKCa1;IK1;KCa3.1;KCa4;Putative Gardos channel

• 实测条带：
• 50kD

• 背景：
• potassium calcium-activated channel subfamily N member 4(KCNN4) Homo sapiens The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008],

• 功能：
• function:Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.,induction:Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells.,similarity:Belongs to the potassium channel KCNN family.,subunit:Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.,tissue specificity:Widely expressed in non-excitable tissues.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Widely expressed in non-excitable tissues.

Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling. TOXICOLOGY LETTERS Toxicol Lett. 2022 Jan;354:1 WB Mouse 1:500 Liver
货号：YN5538

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