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MeCP2 Polyclonal Antibody

货号：YN5516
应用：WB
种属：Human

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靶点：
MeCP2

基因名称：
MECP2

蛋白名称：
Methyl-CpG-binding protein 2

Human Gene Id：
4204

Human Swiss Prot No：
P51608

Mouse Gene Id：
17257

Mouse Swiss Prot No：
Q9Z2D6

Rat Gene Id：
29386

Rat Swiss Prot No：
Q00566

免疫原：
Synthetic Peptide of MeCP2 AA range: 313-363

特异性：
The antibody detects endogenous MeCP2 proteins.

组成：
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:2000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

实测条带：
53kD

背景：
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor

功能：
disease:A chromosomal duplication involving MECP2 is the cause of mental retardation syndromic X-linked Lubs type (MRXSL) [MIM:300260]. Increased dosage of MECP2 appears to be responsible for the mental retardation phenotype. The main features present in affected males are severe to profound mental retardation with onset at birth, axial and facial hypotonia, progressive spasticity predominantly at the lower limbs, seizures and recurrent infections.,disease:Defects in MECP2 are the cause of mental retardation syndromic X-linked type 13 (MRXS13) [MIM:300055]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXS13 patients manifest mental retardation associated with other variable features such as spasticity, episodes of manic

细胞定位：
Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. .

组织表达：
Present in all adult somatic tissues tested.

Effect of Jieduquyuziyin prescription-treated rat serum on MeCP2 gene expression in Jurkat T cells. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 2018 Oct 26 WB Human 1:2000 Jurkat T cell
货号：YN5516