S100 Polyclonal Antibody

    • 货号:YN5481
    • 应用:WB;IHC;IF
    • 种属:Human;Rat;Mouse
      • 靶点:
      • S100
      • 基因名称:
      • S100A1
      • 蛋白名称:
      • Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
      • Human Gene Id:
      • 6271
      • Human Swiss Prot No:
      • P23297
      • Mouse Swiss Prot No:
      • P56565
      • 免疫原:
      • Recombinant Protein of S100
      • 特异性:
      • The antibody detects endogenous S100 protein
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • Protein S100-A1 (S-100 protein alpha chain;S-100 protein subunit alpha;S100 calcium-binding protein A1)
      • 实测条带:
      • 15kD
      • 背景:
      • S100 calcium binding protein A1(S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain.,tissue specificity:Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.,
      • 细胞定位:
      • Cytoplasm . Sarcoplasmic reticulum . Mitochondrion .
      • 组织表达:
      • Highly prevalent in heart (PubMed:12804600, PubMed:1384693). Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693).

      Motor neurons transplantation alleviates neurofibrogenesis during chronic degeneration by reversibly regulating Schwann cells epithelial-mesenchymal transition
      货号:YN5481

      • 产品图片
      • Western blot analysis of 1) 293T, 2) Mouse Brain Tissue with S100 Rabbit pAb diluted at 1:2,000.
      • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using S100Rabbit pAb diluted at 1:200.