- 靶点：
- PTPRM
- 简介：
- >>Cell adhesion molecules;>>Adherens junction
- 基因名称：
- PTPRM PTPRL1
- 蛋白名称：
- Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
- Human Gene Id：
- 5797
- Human Swiss Prot No：
- P28827
- Mouse Swiss Prot No：
- P28828
- 免疫原：
- Synthesized peptide derived from part region of human protein. AA range 21-61
- 特异性：
- PTPRM Polyclonal Antibody detects endogenous levels of protein.
- 组成：
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 实测条带：
- 159kD
- 背景：
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcrip
- 功能：
- catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 MAM domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 4 fibronectin type-III domains.,
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein. Localizes in regions of cell-cell contact. .
- 组织表达：
- Brain,Clones donated by RIKEN,Plasma,Testis,
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- 产品图片
- Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation Signal Transduction and Targeted Therapy Yong Fang WB Human
